Sepsis
Research shows that sepsis is associated with abnormal microvascular perfusion that can lead to decreased oxygen delivery, tissue hypoxia and organ dysfunction. The severity of microcirculatory derangements has been shown to predict mortality.
However, currently available conventional hemodynamic monitoring systems do not provide the information on microcirculatory parameters and how they change in response to treatment. Currently in clinical setting, there are very limited opportunities for doctors to evaluate microcirculation on ongoing basis.
Our bedside hyperspectral imaging device permits to monitor skin oxygen saturation and microcirculation function in real time. It allows doctors to evaluate microcirculation and use it as additional target for guiding treatment in order to reverse life threatening organ failure and reduce sepsis associated deaths and disabilities. .
Results from piloting of our technology have been published in the following scientific papers:
1. Multimodal Device for Real-Time Monitoring of Skin Oxygen Saturation and Microcirculation Function (2019). Link.
2. Relationship of mottling score, skin microcirculatory perfusion indices and biomarkers of endothelial dysfunction in patients with septic shock: an observational study. (2019). Link.
3. Impact of increased mean arterial pressure on skin microcirculatory oxygenation in vasopressor-requiring septic patients: an interventional study. (2019). Link.
4. Infrared Thermography Imaging for Assessment of Peripheral Perfusion in Patients with Septic Shock. (2023). Link.
